Novel properties of the NanoActives™

Solubility and permeability issues often determine the difference between a good drug candidate that is druggable and the one that is not. Pharmaceutical approaches addressing these issues are limited and can have significant impact on activity and/or stability of the active compounds under development.

The Druggability Enabling High Throughput NanoActive™ Technology Platform enables the development of proprietary NanoDrug formulations having the ability to transform multiple physicochemical properties by simple physical transformation. This allows the successful oral administration of drugs with challenging profiles as well as enabling utilization of previously unutilizable alternative routes of administration, such as pulmonary, transdermal, inhalational, buccal and intravenous.

Novel nanostructured drug formulations have demonstrated unique properties that, in a wide and diverse universe of drug structures, enhances solubility, dissolution  rate and bioavailability. These demonstrated properties of the platform represent a significant new option to improve drug utility for “undruggable” novel compounds development or to change the clinical utility and proprietary position of currently marketed drugs.

Novel characteristics of the nanostructured NanoActive™  compounds are:

  • Improving the ADME profile;
  • Increasing bioavailability and improve efficacy and utility;
  • Enhancing solubility, dissolution rate and permeability characteristics that result in improved drugability of novel drugs;
  • Alter  side effect and toxicity profiles of drugs by reducing total administered dose to achieve targeted AUC, T-Max, time to T-Max and half-life, that result from improved pharmacokinetics;
  • Creating novel IP for currently marketed drugs, providing a means to extend proprietary protection and improved clinical use profiles.

 

NanoActive™ compared to the conventional NanoCrystal® technology

Increased solublity of NanoActive™

 

Pampa Assay

  

Increased solubility of NanoActive™

 

Enhanced bioavailability of NanoActive™

 

Instantaneous dissolution of NanoActive™API  tablet