NanoActive™ Advantages 

Poorly soluble drugs generally have low solubility as well as low dissolution velocity and exhibit a small concentration gradient across the intestinal mucosa, which can result in low, variable absorption and a poor therapeutic response. Based on the understanding that not only the solubility but also the rate of drug dissolution are primary driving forces behind improved pharmacokinetic properties the drugs which will be presented were formulated as novel nanostructured particles by using continuous flow nano precipitation technology. The reduction in particle size below 200 nm led to 100s fold higher solubility and 10^3-4 fold increased drug concentration in a stable colloid solution by instantaneous redispersibility of the nanostructured drugs.

As active ingredient developers run out of new chemical entities with high solubility and permeability most compounds that are approved or enter development processes are poorly soluble and/ or have low permeability.
This presents an ever increasing challenge to formulate these molecules into effective and low toxicity products.
On the other hand, this issue is also great opportunity to get ahead of your competition with our revolutionary NanoActive™ Solutions!

The significant benefit that can be achieved by the unique nanostructured particle formation will be applicable for many other established drugs with limited solubility to transform them into instantaneously redispersable form with increased solubility.

Moreover, the virtual high through-put nanoparticle drug delivery technology enables us to design and produce nanostrucured pharmaceutical macromolecules (e.g; polypeptides, polynucleotides) and highly stable nanostructured particles for prolonged release to extend the half life of the drugs.

In today's pharmaceutical industry the „nanoization" of poorly soluble active pharmaceutical ingredients is one of the current strategies for developing new, more potent drugs, as well as enhancing existing drugs. NanGeneX's NanoParmaActives™ have unique chemical and physical properties which are highly dependent on their size and surface morphology, and determine their use in relevant technological applications.

Highly stable nanostructured particles formation for prolonged release

The significant benefit that can be achieved by the unique nanostructured particle formation will be applicable for many other established drugs with limited solubility to transform them into instantaneously redispersable form with increased solubility. Virtual high through-put nanoparticle drug delivery technology enables us to design and produce highly stable nanostructured particles for prolonged release to extend the half life of the drugs.

Advantage of the NanoActives™

• Enhanced bioavailability
• Increased performance of poorly or non-soluble compounds (increased solubility and dissolution rate)
• Reduced dosage/variability
• Reduced side effect
• Reduced food-effect
• New formulation of existing APIs or NCEs
• Nanobiologics
• Prolonged release

Increased solubility of NanoActive™

Penetrated amount of API 

 Enhanced bioavailability of NanoActive™